The Effect of Ethanolic Extract of Justicia Secunda on Kidney Function in Female Wistar Rats

Authors

  • Victor, P.D Rivers State University
  • Ajie, P.C Rivers State University
  • Reuben, E Rivers State University
  • Okpara, P. E Rivers State University
  • George, B.O Rivers State University
  • Fred, B.B Rivers State University
  • Otto, B. Rivers State University

DOI:

https://doi.org/10.47941/ijbs.1148

Keywords:

Electrolytes, Creatinine, Urea

Abstract

Purpose: The kidneys serve as the excretory organ of the body. The assessment of serum creatinine, urea, and electrolytes (Na+, K+, HCO3-, Cl-) are crucial and sensitive biochemical markers that are usually involved in the diagnosis of renal impairments (Agbasi et al. 2010; Tietz, 2008; Yakubu et al. 2003).

Methodology: Thirty-six animals were grouped into 6, with 6 rats in each group. The animals were housed at room temperature in metal cages. Animals in each group had access to clean water and commercial standard rodent pellets. Group 1 (control group) received distilled water, Groups 2-6 were treated orally with low, middle, and high doses of ethanolic extract of Justicia secunda leaves daily for 42 days.

Findings: A significant increase in the level of urea concentration was observed compared to the control. From the present study, Na+, K+, Cl-, and HCO3 increased significantly in the moderate and high dose groups.

Unique contribution to theory, policy and practice: In conclusion, this study indicates that ethanolic extract of Justicia secunda increased the serum level of urea, creatinine, and electrolytes.

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Author Biographies

Victor, P.D, Rivers State University

Department of Human Anatomy, Faculty of Basic Medical Sciences, College of Medical Sciences

Ajie, P.C, Rivers State University

Department of Human Anatomy, Faculty of Basic Medical Sciences, College of Medical Sciences

Reuben, E, Rivers State University

Department of Human Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, Rivers State University

Okpara, P. E, Rivers State University

Department of Human Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences

George, B.O, Rivers State University

Department of Human Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences

Fred, B.B, Rivers State University

Department of Human Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences

Otto, B., Rivers State University

Department of Human Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, Rivers state, Nkpolu Oroworukwo, Port Harcourt, Nigeria

References

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Published

2022-12-13

How to Cite

Victor, V. P., Ajie, A. P., Reuben, R. E., Okpara, O. P. E., George, G. B., Fred, F. B., & Otto, O. B. (2022). The Effect of Ethanolic Extract of Justicia Secunda on Kidney Function in Female Wistar Rats. International Journal of Biological Studies, 2(2), 33–38. https://doi.org/10.47941/ijbs.1148

Issue

Vol. 2 No. 2 (2022)

Section

Articles

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Copyright (c) 2022 Victor, P.D, Ajie, P.C, Reuben, E, Okpara, P. E, George, B.O, Fred, B.B, Otto, B.

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution (CC-BY) 4.0 License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.