A STUDY ON TOTAL LYMPHOCYTE COUNT AND CD4 COUNT IN HIV AFFECTED PATIENTS
DOI:
https://doi.org/10.47941/ijbs.900Keywords:
lymphocyte count, CD4, RBCAbstract
Purpose: The study aimed to assess the total lymphocyte count and CD4 count in HIV affected patients.
Methodology: The approach we used in this study was to gather and analyze a wide range of research articles.
Findings: Worldwide estimates of people living with Human Immunodeficiency Virus was approximately 32 million in 2007 with thousands of people getting infected every day. Most people living with HIV are from developing countries with less than 5% receiving antiretroviral therapy. In 2009, an estimated 2.6 million people became infected out of which approximately 1.8 million were from sub-Saharan Africa. The initiation of antiretroviral therapy is based on CD4 counts of less than 350 cells/mm3 according to the World Health Organization (WHO) and Centre for Disease Control (CDC). The determination of CD4 count however in resource-limited localities is difficult. A total lymphocyte count (TLC) of <1200 cells/mm3 has been recommended in addition to WHO staging (stage II) of the disease, for the initiation of antiretroviral therapy in such localities.
Unique contribution to theory, practice and policy: The use of absolute lymphocyte count as a marker for HIV progression has been argued in many quarters over the years. Studies have suggested that when the absolute lymphocyte count is used in conjunction with blood hemoglobin, it gives a more sensitive marker for HIV progression with other studies discrediting the use of TLC in such settings.
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Agrawal, P. B., Rane, S. R., & Jadhav, M. V. (2016). Absolute lymphocyte count as a surrogate Marker of CD4 count in monitoring HIV infected individuals: A prospective study. Journal of Clinical and Diagnostic Research: JCDR, 10(5), EC17.
Angelo, A. L. D., Angelo, C. D., Torres, A. J. L., Ramos, A. M. C., Lima, M., Netto, E. M., & Brites, C. (2007). Evaluating total lymphocyte counts as a substitute for CD4 counts in the follow up of AIDS patients. Brazilian Journal of Infectious Diseases, 11, 466-470.
Akinola, N. O., Olasode, O., Adediran, I. A., Onayemi, O., Murainah, A., Irinoye, O., ... & Durosinmi, M. A. (2004). The search for a predictor of CD4 cell count continues: total lymphocyte count is not a substitute for CD4 cell count in the management of HIV-infected individuals in a resource-limited setting. Clinical Infectious Diseases, 39(4), 579-581.
Lepri, A. C., Katzenstein, T. L., Ullum, H., Phillips, A. N., Skinhøj, P., Gerstoft, J., & Pedersen, B. K. (1998). The relative prognostic value of plasma HIV RNA levels and CD4 lymphocyte counts in advanced HIV infection. Aids, 12(13), 1639-1643.
Maini, M. K., Gilson, R. J., Chavda, N. A., Gill, S., Fakoya, A., Ross, E. J., ... & Weller, I. V. (1996). Reference ranges and sources of variability of CD4 counts in HIV-seronegative women and men. Sexually Transmitted Infections, 72(1), 27-31.
Miller, V., Mocroft, A., Reiss, P., Katlama, C., Papadopoulos, A. I., Katzenstein, T., ... & EuroSIDA Study Group*. (1999). Relations among CD4 lymphocyte count nadir, antiretroviral therapy, and HIV-1 disease progression: results from the EuroSIDA study. Annals of internal medicine, 130(7), 570-577.
Nnoruka, E. N., Chukwuka, J. C., & Anisuiba, B. (2007). Correlation of mucocutaneous manifestations of HIV/AIDS infection with CD4 counts and disease progression. International Journal of Dermatology, 46, 14-18.
RodrÃguez, J. O., Prieto, S. E., Correa, C., Prez, C. E., Mora, J. T., Bravo, J., ... & Ãlvarez, L. F. (2013). Predictions of CD4 lymphocytes' count in HIV patients from complete blood count. BMC Medical Physics, 13(1), 1-6.
The President's Emergency Plan for AIDS Relief (PEPFAR, 2011), Next Generation Indicators Reference Guide (http://www.pepfar.gov).
Tinarwo, P., Zewotir, T., Yende-Zuma, N., Garrett, N. J., & North, D. (2019). An evaluation to determine the strongest CD4 count covariates during HIV disease progression in women in South Africa. Infectious diseases and therapy, 8(2), 269-284.
Wande, I. N., Fuadi, M. R. U., & Hadi, S. (2019). The Correlation between total lymphocyte count, hemoglobin levels, lymphocyte/leukocyte ratio (LLR), and lymphocyte/neutrophil ratio (LNR) to CD4 levels in patients with Human Immunodeficiency Virus infection at Sanglah Hospital. Age (years), 34, 1-51.
WHO approved draft treatment guidelines for HIV-infected people in resource limited settings. In: The Hopkin's HIV report. The John Hopkins University AIDS Service 2002; 14:1-4. Available at: http://www. hopkins-aids.edu.
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Copyright (c) 2022 Dennis Amboja
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