Effect of Cnidoscolus Aconitifolius on Some Biochemical Parameters in Wistar Rats Orally Exposed to Bonny Light Crude Oil


  • S.C. Onuoha University of Port Harcourt, Rivers state, Nigeria
  • C.C Chukwuma University of Port Harcourt, Rivers state, Nigeria
  • K.A. Okari Rivers State University Nkpolu, Port Harcourt, Rivers State, Nigeria


Abstract views: 88
PDF downloads: 112


Crude oil, Wistar rats, hematological, folklore medicine, Cnidoscolus aconitifolius


Purpose: Crude oil is used in folklore medicine to treat various forms of diseases and in most cases in combination with medicinal plants. Studies have reported that Cnidoscolus aconitifolius possess medicinal properties. The present study investigated the effect of different concentration of Bonny light crude oil and Cnidoscolus aconitifolius on some biochemical parameters of Wistar rats. The rats were orally exposed to different concentrations of Bonny light crude oil and Cnidoscolus aconitifolius leaf extract individually and in combination.

Methodology: After an exposure period of 21days, the results revealed that Bonny light crude oil and the leaf extract at concentrations of 250 and 500mgkg-1b.wt can induce damage to the liver and kidney within 21days of consecutive administration. This is shown in results of histological analysis gotten from the liver and kidney tissues.

Findings: This study revealed that the induction of the leaf extract of Cnidoscolus aconitifolius and Bonny light crude oil at concentrations of 250 and 500mgkg-1b.wt for 21days may affect the liver and kidney.

Contributions to theory, policy and practice:Therefore, it is recommended that the use of this leaf extract and Bonny light crude oil at concentrations similar to the ones used in this study should be discontinued.


Download data is not yet available.

Author Biographies

S.C. Onuoha, University of Port Harcourt, Rivers state, Nigeria

Department of Biochemistry

C.C Chukwuma, University of Port Harcourt, Rivers state, Nigeria

Department of Biochemistry


Achuba, F.I. and Offor, C. (2020): Effects of siam weed (Chromolaena odorata) leaf extract on crude oil induced toxicity. Galician Med. J. 27(10) 21802

Adedara I.A., Teberen R., Ebokaiwe A.P., Ehwerhemuepha T., Farombi E.O. (2012): Induction of oxidative stress in liver and kidney of rats exposed to Nigerian Bonny light crude oil. Env. Toxicol. 27(6): 372-379

Anil. P, Anjali, O.S, Kiran, B.N., Mukesh, K.G. (2021): Cnidoscolus aconitifolius: Nutritional, phytochemical composition and Health benefits-A review. Bioactive compds Health and Dis. 4(11): 260-286

Ayman Y.I.E. (2014): Oil spills: Impact on water quality and microbial community of the Nile River Egypt. Int. J. Environ. 3(4): 192-198

Babalola, J.O. and Opeyemi, O.A. (2015): Effect of processing methods on Nutritional composition, phytochemicals and anti-nutrient properties of Chaya leaf (Cnidoscolus aconitifolius) African J. Food Sci 9(12): 560-565

Barton C.(2014): In Encylopedia of Toxicology. Third Edition

Chibuike S.A., Obinna A.O. and Isaac O. (2012): Effects of Excravos light crude oil on liver enzyme markers activity and malondialdehyde levels of rats. J. of Env. And occu. Sci. 1(3): 1

Chukwudoruo C.S., Osuji-Kalu-Ibe N.C., Igwe K.O., Iheme C.I., Favour N.U. and Mba B.A. (2021):Serum total protein concentration and liver enzymes activities in albino rats model administered with ethanolic leaf extract of Ficus capensis. Afr. J. of Biotech. 20(4): 164-168

Grubben, G.J.H., Denton, O.A.(2004): Plant Resources of Tropical African. 2; vegetables. PROTA founda. 200-201

Hilscher M, and Sanchez W. (2016): Congestive hepatopathy. Clin. Liver Dis. 8: 68-71

Imafidon K.E. and Okunrobo L.O. (2012): Study on biochemical indices of liver function tests of albino rats supplemented with three sources of vegetable oils. Nig. J. of basic and Appl. Sci. 20(2): 105-110

Nafagha-Lawal M.O., Sikoki F.D., Georgewill O.A. (2018): The effect of crude oil on hematological Indices of the Frog, Ptychadena mascariensis in the Niger Delta, Nigeria. J. of Eniv. Sci.,Toxico and food tech. 12(7): 61-64

Ojo A.O., Jaja S.I., Olubayode D.B.L and Taiye F.F. (2015): Effects of Nigerian Ekete light crude oil on plasma Electrolytes, packed cell volume (PCV) and lipid profile in Wistar (Rattus norvegicus) rats. Afr. J. Biotechnol. 14: 2047-2051

Pazhayattil G.S and Shirali A. (2014): Drug-induced impairment of renal function. Int. J. Nephrol. Renovascular Dis. 7: 457-468

Penghal, A., Janghu, S., Virkar, K., Gat, Y., Kumar, V. and Chhikara, N. (2018): Potential non-diary probiotic products- a healthy approach. Food Bio. 21: 80-89

Pillai, K.K., Chidambaranathan, N., Halith, M.M., Jayaprakash, S. and Narayanan, N.(2012): Anti-hyperglycemic effects of alcohol extracts of Cnidoscolus chayamansa in experimental diabetes and their effects on key metabolic enzymes involved in carbohydrates metabolism. Int. J. of Res. In Pharm. and chem. 2(1): 164-178

Simon G.K. and Jean P.B. (2019): Impacts of crude oil exploration and production on environment and its implications on human health: South Sudan Review. Int. J. of Sci. and Res. Pub. (IJSRP) 9(4): 8836

Singha, P.K., Roy, S. and Dey, S. (2007): Protective activity of Androgra pholide and Arabinogelactan proteins from Andrographis paniculate Nees against ethanol-induced toxicity in mice. J. Ethanopharm. 111: 13-21

Zhang L., Bo Yuan, Wang H. and Gao Y. (2015): Therapeutic effect of Agaricus brasiliensis on phenylhydrazine-induced neonatal jaundice in rats. Biomed Res. Int. 651218

Zhelev Z.H., Mollova D, Boyadziev P. (2016): Morphological and hematological parameters of Carasius gibelio (pisces: Gyprinidae) in conditions of anthropogenic pollution in Southern Bulgaria. Use of hematological parameters. Trakia J. of Sci. 1: 1-15




How to Cite

Onuoha, S. ., Chukwuma , C. ., & Okari, K. . (2023). Effect of Cnidoscolus Aconitifolius on Some Biochemical Parameters in Wistar Rats Orally Exposed to Bonny Light Crude Oil. International Journal of Health Sciences, 6(2), 9–27. https://doi.org/10.47941/ijhs.1210