Toxoplasmosis in Public Health: Risks, Diagnosis and Therapeutic

Authors

  • Isabelle Santos Rosa de Souza State University of Rio de Janeiro
  • Giullyane Tardivo Costa State University of Rio de Janeiro
  • Olga Maria de Jesus Souza State University of Rio de Janeiro
  • Gabriella Oliveira Alves Moreira de Carvalho State University of Rio de Janeiro; Carlos Chagas Filho Biophysics Institute; Federal University of Rio de Janeiro;
  • Sergian Vianna Cardozo State University of Rio de Janeiro
  • Sergio Henrique Seabra Universidade Estadual do Norte Fluminense Darcy Ribeiro
  • Fabio da Silva de Azevedo Fortes State University of Rio de Janeiro

DOI:

https://doi.org/10.47941/ijhs.2363

Keywords:

Toxoplasmosis, Toxoplasma gondii, Clinical aspects, Parasitic infection.

Abstract

Purpose: Based on the notoriety of the prevalence of the disease in the current context, this paper aims to cite the main forms of treatment currently applied, highlighting the particularities of each medication used, in addition to highlighting the future perspectives in relation to the disease and preventive measures.

Methodology: To produce the article, a literature review was carried out based on books, epidemiological and experimental papers through searches in Google, academic databases and PubMed.

Findings: Recent studies show a possible relationship between toxoplasmosis and other diseases of the Central Nervous System, such as Parkinson's. Despite years of research aimed at producing an effective vaccine against the disease, it has not yet been possible to obtain one, although there is progress.

Unique Contribution to Theory, Policy and Practice: By reviewing data already present in the literature, it is possible to better clarify which are the best forms of diagnosis, as well as the development of new treatments. The graphical analysis of the results indicated fewer studies about risk factors and prevention methods, showing a lack of discussion about these topics and a need to spread this information to try to lower the prevalence of the disease. Therefore, the evolution of disease diagnosis techniques helps in the beginning of treatment, preventing the worsening of the condition in more susceptible people.

Downloads

Download data is not yet available.

Author Biographies

Isabelle Santos Rosa de Souza, State University of Rio de Janeiro

Laboratory of Cellular and Molecular Therapy and Physiology Prof. Antonio Carlos Campos de Carvalho; DEPBIO, FCBS,

Giullyane Tardivo Costa, State University of Rio de Janeiro

Laboratory of Cellular and Molecular Therapy and Physiology Prof. Antonio Carlos Campos de Carvalho; DEPBIO, FCBS

Olga Maria de Jesus Souza, State University of Rio de Janeiro

Laboratory of Cellular and Molecular Therapy and Physiology Prof. Antonio Carlos Campos de Carvalho; DEPBIO, FCBS

Postgraduate Program in Translational Biomedicine (BioTrans)

Gabriella Oliveira Alves Moreira de Carvalho, State University of Rio de Janeiro; Carlos Chagas Filho Biophysics Institute; Federal University of Rio de Janeiro;

Laboratory of Cellular and Molecular Therapy and Physiology Prof. Antonio Carlos Campos de Carvalho

 

Sergian Vianna Cardozo, State University of Rio de Janeiro

Laboratory of Cellular and Molecular Therapy and Physiology Prof. Antonio Carlos Campos de Carvalho; DEPBIO, FCBS

Postgraduate Program in Translational Biomedicine (BioTrans)

Sergio Henrique Seabra, Universidade Estadual do Norte Fluminense Darcy Ribeiro

Laboratory of Cellular and Tissue Biology/Center of Biosciences and Biotechnology (LBCT/CBB/UENF)

Fabio da Silva de Azevedo Fortes, State University of Rio de Janeiro

Laboratory of Cellular and Molecular Therapy and Physiology Prof. Antonio Carlos Campos de Carvalho; DEPBIO, FCBS

Postgraduate Program in Translational Biomedicine (BioTrans)

References

ATTIAS, Márcia et al. The life-cycle of Toxoplasma gondii reviewed using animations. Parasites & vectors, v. 13, p. 1-13, 2020.

BAHIA, Mônica Dias; ORÉFICE, Fernando. CLINICAL ASPECTS OF RETINOCHOROIDITIS LESIONS IN CHILDREN WITH CONGENITAL TOXOPLASMOSIS. In: Recent Advances in Uveitis: Proceedings of the Third International Symposium on Uveitis, Brussels, Belgium, May 24-27, 1992. Kugler Publications, 1993. p. 203.

BALSARI A, Poli G etal. ELISA for toxoplasma antibody detection: a comparison with other serodiagnostic tests. J Clin Pathol. 1980.

BAQUERO-ARTIGAO, F. et al. Guía de la Sociedad Española de Infectología Pediátrica para el diagnóstico y tratamiento de la toxoplasmosis congénita. In: Anales de Pediatría. Elsevier Doyma, 2013. p. 116. e1-116. e16.

BARB SM, Patel AV, Young LH. Toxoplasmic Retinitis: To Treat or Not to Treat and With What Drug? Int Ophthalmol Clin. 2015.

BARBOSA, Helene Santos; MUNO, Renata Morley de; MOURA, Marcos de Assis. O Ciclo Evolutivo. In: DE SOUZA, Wanderley; BELFORT JR., Rubens. Toxoplasmose & Toxoplasma gondii. Rio de Janeiro: Editora Fiocruz, 2014. p. 33-45.

BARROS, Mariana et al. Vaccines in congenital toxoplasmosis: advances and perspectives. Frontiers in Immunology, v. 11, p. 621997, 2021.

BRANCO, Bráulio Henrique Magnani; ARAÚJO, Silvana Marques; FALAVIGNA-GUILHERME, Ana Lúcia. Prevenção primária da toxoplasmose: conhecimento e atitudes de profissionais de saúde e gestantes do serviço público de Maringá, estado do Paraná. Sci Med, v. 22, n. 4, p. 185-90, 2012.

Brasil. Ministério da Saúde. Gabinete do Ministro. Toxoplasmose. Brasília, 2009.

BUITRAGO, Luis Felipe Lemus; ASCENCIO, Diego José Osegueda; RODRÍGUEZ, Verónica Cecilia Fuentes. Seroprevalencia de Toxoplasma gondii y su relación con trastornos mentales en adultos. Alerta, Revista científica del Instituto Nacional de Salud, v. 7, n. 1, p. 111-117, 2024.

BURG JL, Grover CM, Pouletty P, Boothroyd JC. Direct and sensitive detection of a pathogenic protozoan, Toxoplasma gondii, by polymerase chain reaction. J Clin Microbiol. 1989.

CARDOSO, Ana Paula et al. , Development, structural, spectroscopic and investigation of new complexes relevant as anti-toxoplasma metallopharmacs. Journal of Molecular Structure 1265(3). 2022.

Commodaro AG, Belfort RN, Rizzo LV, Muccioli C, Silveira C, Burnier MN Jr, Belfort R Jr. Ocular toxoplasmosis: an update and review of the literature. Mem Inst Oswaldo Cruz. 2009.

DA SILVA, José Eduardo Marques; MARINHO, Glenda Lidice de Oliveira Cortez; ROMEIRO, Edenilze Teles. TOXOPLASMOSE SUÍNA: REVISÃO DE LITERATURA. Revista Expressão Científica (REC), v. 5, n. 1, p. 60-70, 2020.

DAHER, Darine et al. Comprehensive overview of Toxoplasma gondii-induced and associated diseases. Pathogens, v. 10, n. 11, p. 1351, 2021.

DUARTE, Maria Irma Seixas; ANDRADE JÚNIOR, Heitor Franco de. Toxoplasmose. Patologia, 1994.

DUBEY, J. P. et al. Distribution of Toxoplasma gondii tissue cysts in commercial cuts of pork. Journal of the American Veterinary Medical Association, v. 188, n. 9, p. 1035-1037, 1986.

DUBEY, J. P.; BEATTIE, C.P. Toxoplasmosis in Humans (Homo sapiens). In: DUBEY, J. P.; BEATTIE, C.P.Toxoplasmosis of animals and humans. Beltsville: CRC Press Taylor & Francis Group, 1988. p. 73-93.

DUNAY, Ildiko Rita et al. Treatment of toxoplasmosis: historical perspective, animal models, and current clinical practice. Clinical microbiology reviews, v. 31, n. 4, p. 10.1128/cmr. 00057-17, 2018.

ESTEVES, Madalena Fernandes. Estabelecer culturas de organóides de intestino como modelo para estudar a expressão de genes da fase sexuada de Toxoplasma gondii. Orientador: Doutora Dulce Maria Metelo Fernandes dos Santos. 77. Dissertação-Tecnologias Moleculares em Saúde, Instituto Politécnico de Lisboa, 2022. Disponível em: <http://hdl.handle.net/10400.21/15023>. Acesso em: 05 mai. 2024.

ESTEVINHO, Maria Fernanda; Soares-Fortunato, JM. Dopamina e receptores. Revista Portuguesa de Psicossomática. vol. 5, núm. 1, junho, 2003, pp. 21-31. 2003

FLEGR, J. Effects of toxoplasma on human behavior. Schizophr Bull. 2007.

FRENKEL, J. K. Toxoplasma in and around us. Bioscience, v. 23, n. 6, p. 343-352, 1973.

FRENKEL, J. K.; DUBEY, J. P.; MILLER, Nancy L. Toxoplasma gondii in cats: fecal stages identified as coccidian oocysts. Science, v. 167, n. 3919, p. 893-896, 1970.

FUGLEWICZ AJ, PIOTROWSKI P, STODOLAK A. Relationship between toxoplasmosis and schizophrenia: A review. Adv Clin Exp Med. 2017.

GARIN JP, EYLES DE. Le traitement de la toxoplasmose expérimentale de la souris par la spiramycine [Spiramycin therapy of experimental toxoplasmosis in mice]. Presse Med (1893). 1958.

GRANATO, Celso F. H.; JUNIOR, Inaurei José Paulini. Diagnóstico Laboratorial da Toxoplasmose. In: DE SOUZA, Wanderley; BELFORT JR., Rubens. Toxoplasmose & Toxoplasma gondii. Rio de Janeiro: Editora Fiocruz, 2014. p. 127-135.

GROËR MW et al. . Prenatal depression and anxiety in Toxoplasma gondii-positive women. Am J Obstet Gynecol. 2011.

GRZYBOWSKI, Marcin M. et al. Towards vaccine against toxoplasmosis: evaluation of the immunogenic and protective activity of recombinant ROP5 and ROP18 Toxoplasma gondii proteins. Parasitology research, v. 114, p. 4553-4563, 2015.

GUIMARÃES, Luiz Felipe et al. Infecção primária por Toxoplasma gondii com acometimento do sistema nervoso central em receptor de transplante hepático. The Brazilian Journal of Infectious Diseases, v. 26, p. 102213, 2022.

HALONEN, S. K.; WEISS, L. M. Toxoplasmosis. Handbook Clinical Neurology, 114. 2013.

HAVERKOS HW. Assessment of therapy for toxoplasma encephalitis. The TE Study Group. Am J Med. 1987.

HOLLAND GN, LEWIS KG. An update on current practices in the management of ocular toxoplasmosis. Am J Ophthalmol. 2002.

HOMAN WL, VERCAMMEN M, DE BRAEKELEER J, VERSCHUEREN H. Identification of a 200- to 300-fold repetitive 529 bp DNA fragment in Toxoplasma gondii, and its use for diagnostic and quantitative PCR. Int J Parasitol. 2000.

HOWE, Daniel K.; SIBLEY, L. David. Toxoplasma gondii comprises three clonal lineages: correlation of parasite genotype with human disease. Journal of infectious diseases, v. 172, n. 6, p. 1561-1566, 1995.

Jones-Brando L, Torrey EF, Yolken R. Drugs used in the treatment of schizophrenia and bipolar disorder inhibit the replication of Toxoplasma gondii. Schizophr Res. 2003

Kortagere S. Screening for small molecule inhibitors of Toxoplasma gondii. Expert Opin Drug Discov. 2012.

LYONS, Russell E.; MCLEOD, Rima; ROBERTS, Craig W. Toxoplasma gondii tachyzoite–bradyzoite interconversion. Trends in parasitology, v. 18, n. 5, p. 198-201, 2002.

MINTO A, ROBERTS FJ. The psychiatric complications of toxoplasmosis. Lancet. 1959

MINTO, A. et al. The psychiatric complications of toxoplasmosis. The Psychiatric Complications of Toxoplasmosis., p. 1180-82, 1959.

Montoya JG, Remington JS. Management of Toxoplasma gondii infection during pregnancy. Clin Infect Dis. 2008.

MONTOYA, J. G.; LIESENFELD, O. Toxoplasmosis. Lancet 363, 1965 e 1976. 2004.

MONTOYA, Jose G. Laboratory diagnosis of Toxoplasma gondii infection and toxoplasmosis. The Journal of infectious diseases, v. 185, n. Supplement_1, p. S73-S82, 2002.

MORAL, Juan Miguel Martin. Toxoplasma gondii e toxoplasmose: epidemiologia, patologia, diagnóstico e novos tratamentos. Orientador: Doutora Maria Guilhermina Martins Moutinho. 97.Tese- Ciências Farmacêuticas, Instituto Politécnico de Lisboa, 2020. Disponível em: < https://comum.rcaap.pt/bitstream/10400.26/35097/1/Martin%20Moral_Juan%20Miguel.pdf>. Acesso em: 23 out. 2024.

MOURA, Ivone Pereira da Silva et al. Conhecimento e comportamento preventivo de gestantes sobre Toxoplasmose no município de Imperatriz, Maranhão, Brasil. Ciência & Saúde Coletiva, v. 24, p. 3933-3946, 2019.

NAYERI T et al.Toxoplasma gondii: A possible etiologic agent for Alzheimer's disease. Heliyon. 2021.

NETO, Vicente Amato. Tratamento da toxoplasmose. Revista de Medicina, v. 64, n. 1, p. 8-9, 1982.

NICOLAU, Wilian; DE ASSIS, Lício Marques. Catecolaminas: síntese, metabolismo e ações. Instituto de Energia Atômica. IEA n° 201. 1969.

NOUROLLAHPOUR SHIADEH, M. et al. The correlation between Toxoplasma gondii infection and prenatal depression in pregnant women. European Journal of Clinical Microbiology & Infectious Diseases, v. 35, p. 1829-1835, 2016.

O'CONNOR GR, REMINGTON JS. Therapy of toxoplasmic retinochoroiditis. Arch Ophthalmol. 1964.

OLIVEIRA, Anaylle Leitão et al. Fatores relacionados com a suscetibilidade e transmissibilidade da toxoplasmose em gestantes uma revisão sistemática. Research, Society and Development, v. 12, n. 6, p. e17512642249-e17512642249, 2023.

ORTIZ-GUERRERO, Gloria et al. Pathophysiological mechanisms of cognitive impairment and neurodegeneration by Toxoplasma gondii infection. Brain sciences, v. 10, n. 6, p. 369, 2020.

Paraná. Secretaria de Saúde. Governo do Paraná. Toxoplasmose. Paraná, 2021.

PEZZELLA, N. et al. Involvement of calcium and calmodulin in Toxoplasma gondii tachyzoite invasion. European journal of cell biology, v. 74, n. 1, p. 92-101, 1997.

PIETKIEWICZ, H. et al. Usefulness of Toxoplasma gondii-specific recombinant antigens in serodiagnosis of human toxoplasmosis. Journal of Clinical Microbiology, v. 42, n. 4, p. 1779-1781, 2004.

PRANDOVSKI E, GASKELL E, MARTIN H, DUBEY JP, WEBSTER JP, MCCONKEY GA. The neurotropic parasite Toxoplasma gondii increases dopamine metabolism. PLoS One. 2011

QUEFURTH HW, LAFERLA FM. Alzheimer's disease. N Engl J Med. 2010.

QUEIROZ, Wendel Silva; DE MEDEIRO, Renata Lívia Fonseca Moreira; DA SILVA, Talina Carla; COELHO, Ricardo Lourenço. Coriorretinite em pacientes infectados com Toxoplasma gondii: uma revisão integrativa da Literatura. Revista Interdisciplinar em Saúde, Cajazeiras, 5 (6): 1529-1542, out./dez. 2018

Santa Catarina. Secretaria de Saúde. Governo de Santa Catarina. Manual técnico de orientações sobre o manejo da toxoplasmose. Santa Catarina, 2022.

SANCHEZ, Syrian G. et al. The apicoplast is important for the viability and persistence of Toxoplasma gondii bradyzoites. Proceedings of the National Academy of Sciences, v. 120, n. 34, p. e2309043120, 2023.

SANTOS, Vinicius de Resende et al. Há relação entre Toxoplasmose e doenças neuropsiquiátricas?. Journal of Medicine and health promotion. v. 2, n. 3, out/dez 2017, p. 752-761. 2017

SILVA, A. F. et al. Toxoplasma gondii in tissues of sheep slaughtered for human consumption in a highly endemic area for toxoplasmosis in Brazil. Veterinary Parasitology: Regional Studies and Reports, v. 29, p. 100688, 2022.

SILVA, V. L.; FARIAS, R. de S.; HARA, R. T. e S.; SANTIAGO, M. L. da C.; LIMA, A. G. L.; DOS SANTOS, T. F. C.; LIMA FILHO, A. C. M.; FIGUEIREDO, C. S. S. e S.Toxoplasmose ocular e suas repercussões: Uma Revisão Bibliográfica. Revista Foco, [S. l.], v. 16, n. 12, p. e3871, 2023.

SOUZA, Wanderley de. Aspectos ultraestruturais do processo de divisão do Toxoplasma gondii. Revista da Sociedade Brasileira de Medicina Tropical, v. 8, p. 45-65, 1974.

SPONCHIADO, Mariana Pastre; DA SILVA, Alliny Beletini. Alterações clínicas em crianças com toxoplasmose congênita na cidade de Cascavel/PR. Research, Society and Development, v. 12, n. 6, p. e0612641939-e0612641939, 2023.

STIBBS, H. H. (1985). Changes in brain concentrations of catecholamines and indoleamines in Toxoplasma gondii infected mice. Annals of Tropical Medicine & Parasitology, 79(2), 153–157. 1983

STORCHILO, Heloisa Ribeiro. Identificação de biomarcadores para o diagnóstico da toxoplasmose aguda e congênita. 2020.

TANCREDI, Virginia et al. Tumor necrosis factor alters synaptic transmission in rat hippocampal slices. Neuroscience letters, v. 146, n. 2, p. 176-178, 1992.

TEIL J et al. . Treatment of Congenital Toxoplasmosis: Safety of the Sulfadoxine-Pyrimethamine Combination in Children Based on a Method of Causality Assessment. Pediatr Infect Dis J. 2016.

TORQUATO, João Vitor Monteiro Bastos et al. Toxoplasmose e gestação: revisão de literatura. Brazilian Journal of Development, v. 8, n. 5, p. 35265-35272, 2022.

VOLLER A, Bidwell de, BARTLETT A, Fleck DG, PERKINS M, Oladehin B. A microplate enzyme-immunoassay for toxoplasma antibody. J Clin Pathol. 1976.

WEAVER, R. F. Molecular biology. Lawrence: University of Kansas, 2001. 880 p.

ZHANG, Nian-Zhang et al. Evaluation of immune responses in mice after DNA immunization with putative Toxoplasma gondii calcium-dependent protein kinase 5. Clinical and Vaccine Immunology, v. 21, n. 7, p. 924-929, 2014.

ZHANG, Yang et al. Toxoplasma gondii secretory proteins and their role in invasion and pathogenesis. Microbiological research, v. 227, p. 126293, 2019.

Downloads

Published

2024-11-22

How to Cite

De Souza, I. S. R., Tardivo Costa, G., Souza, O. M. de J., De Carvalho, G. O. A. M., Cardozo, S. V., Seabra, S. H., & Fortes, F. da S. de A. (2024). Toxoplasmosis in Public Health: Risks, Diagnosis and Therapeutic. International Journal of Health Sciences, 7(8), 1–18. https://doi.org/10.47941/ijhs.2363

Issue

Section

Articles