LIPID PEROXIDATION AND EXPRESSION OF PARAOXONASE-1 (PON-1) GENE IN PATIENTS WITH PREECLAMPSIA
DOI:
https://doi.org/10.47941/ijhs.830Keywords:
Preeclampsia, Lipid Peroxidation, Paraoxonase-1 Oxidative Stress, MalondialdehydeAbstract
Purpose: To evaluate lipid peroxidation and expression of paraoxonase-1 (pon-1) gene in patients with preeclampsia.
Methodology: The study comprised of 160 participants, in which 80 were normotensive pregnant women (Group A) and 80 were preeclamptic pregnant women (Group B). Serum MDA levels and PON-1 gene activity were estimated. The expression of data was subjected to statistical analysis using SPSS version 20.0. One-way analysis of variance (ANOVA) was used to compare the test samples, p value <0.05 was considered significant.
Findings: MDA levels were significantly elevated in preeclamptic pregnant women when compared to normotensive. Also, PON-1 gene expression levels were significantly decreased in preeclamptic pregnant women when compared to normotensive.
Unique contribution to theory, practice and policy: The significant increase in the plasma level of Malondialdehyde and decreases expression of PON-1 gene could be responsible for the presence of oxidative stress and its associated complications in PE patients.
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