Expected Adverse Pregnancy Outcome Among HIV-Positive Women on ART before and during Pregnancy Delivered at Mwananyamala and Amana Regional Referral Hospital, Dar es salaam Region Tanzania from December 2018 to July 2019
DOI:
https://doi.org/10.47941/ijhs.3908Keywords:
Adverse Pregnancy Outcome, HIV positive, Pregnancy, Birth outcomes, ART use, Pregnant women.Abstract
Purpose. The aim of the study was to determine any adverse pregnancy outcomes among HIV-positive pregnant women delivered at Mwananyamala and Amana reginal referral Hospitals in Dar es Salaam Tanzania.
Methodology: Descriptive cross-sectional study was used and total of 322 participants were enrolled in this study. The study was conducted at Dar es Salaam Region Tanzania Amana and Mwananyamala hospital. Non-probability sampling (convenient sampling) in which all HIV positive pregnant women who were on ART before and during pregnancy was included in the study.
Findings: In this study prevalence of adverse pregnancy outcome among HIV pregnancy women on ART was found to be 19.5%; delivery by caesarian section, and 1.24%; by assisted delivery, while 27.02%; had preterm delivery which is higher compared to the study conducted in Tanzania Urban and Rural in 2014 where by the prevalence was 11%. This result was also contrary to the study conducted in Zanzibar prevalence was found to be lower by 3%.
Unique Contribution to Theory, Practice and Policy: This study has found that postnatal women who were started ART during pregnancy were at higher risk of getting newborn with adverse outcome compared to those who started ART before pregnancy
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1. Chen JY, Ribaudo HJ, Souda S, Pwerekh N, Ogwu A, Lockman S, et al. Highly Active Antiretroviral Therapy and Adverse Birth Outcomes Among HIV-Infected Women in Botswana. J Infect Dwas [Internet]. 2012 Dec 1 [cited 2019 Apr 12];206:1695–705.
2. Kebede B, Andargie G, Gebeyehu A. Birth outcome and correlates of low birth weight and preterm delivery among infants born to HIV-infected women in public hospitals of Northwest Ethiopia. Health (Irvine Calif) [Internet]. 2013 [cited 2019 Apr 12];05(07):
25–34.
3. Pustil R. UN Global AIDS Update 2016. UNAIDS. 2016.
4. Leshabari. Prevalence of the Human Immunodeficiency Virus, other sexually transmitted infections, and health-related perceptions, reflections, experiences and practices among men having sex with men in Dar es Salaam - For ansatte - Universitetet i Oslo - For ansatte - Universitetet i Oslo [Internet]. 2013 [cited 2019 Apr 12].
5. (UNAIDS) JUNP on H, Joint United Nations Programme on HIV/AIDS (UNAIDS). The Gap Report UNAIDS. Geneva: UNAIDS. 2014;
6. (UNAIDS) JUNP on H. Progress towards the 90-90-90 targets Ending AIDS GLOBAL AIDS UPDATE | 2017 [Internet]. 2017 [cited 2019 Apr 12].
7. Community Development G, Elderly and Children. Tanzania HIV Impact Survey [Internet]. 2016 [cited 2019 Apr 12]. Available from: https://phia.icap.columbia.edu/wp-content/uploads/2017/11/Tanzania_SummarySheet_A4.Englwash.v19.pdf
8. Gamell A, Luwanda LB, Kalinjuma AV, Samson L, Ntamatungiro AJ, Wewasser M, et al. Prevention of mother-to-child transmwassion of HIV Option B+ cascade in rural Tanzania: The One Stop Clinic model. Charpentier C, editor. PLoS One [Internet]. 2017
9. Sabin CA, Lundgren JD. The natural history of HIV infection. Curr Opin HIV AIDS [Internet]. 2013 Jul [cited 2019 Apr 12];8(4):311–7.
10. Sax PE. The natural history and clinical features of HIV infection in adults and adolescents - UpToDate [Internet]. UpToDate. 2018 [cited 2019 Apr 12].
11. Habib NA, Daltveit AK, Bergsjø P, Shao J, Oneko O, Lie RT. Maternal HIV status and pregnancy outcomes in northeastern Tanzania: A regwastry-based study. BJOG An Int J Obstet Gynaecol. 2015;
12. Calvert C, Ronsmans C. HIV and the rwask of direct obstetric complications: a systematic review and meta-analyswas. PLoS One [Internet]. 2013 [cited 2019 Apr 12];8:e74848. (12)
13. Zaba B, Calvert C, Marston M, Wasingo R, Nakiyingi-Miiro J, Lutalo T, et al. Effect of HIV infection on pregnancy-related mortality in sub-Saharan Africa: secondary analyses of pooled community-based data from the network for Analysing Longitudinal Population-based HIV/AIDS data on Africa (ALPHA). Lancet [Internet]. 2013 May 18 [cited 2019 Apr 12];381(9879):1763–71.
14. Haeri S, Shauer M, Dale M, Leslie J, Baker AM, Saddlemire S, et al. Obstetric and newborn infant outcomes in human immunodeficiency virus–infected women who receive highly active antiretroviral therapy. Am J Obstet Gynecol [Internet]. 2009 Sep [cited 2019 Apr 12];201(3):315.e1-315.e5.
15. Darak S, Darak T, Kulkarni S, Kulkarni V, Parchure R, Hutter I, et al. Effect of Highly Active Antiretroviral Treatment (HAART) During Pregnancy on Pregnancy Outcomes: Experiences from a PMTCT Program in Western India. AIDS Patient Cwere STDS [Internet]. 2013 Mar [cited 2019 Apr 12];27:163–70.
16. Wedi COO, Kirtley S, Hopewell S, Corrigan R, Kennedy SH, Hemelaar J. Perinatal outcomes associated with maternal HIV infection: a systematic review and meta-analyswas. Lancet HIV [Internet]. 2016 Jan 1 [cited 2019 Apr 12];3:e33–48. (14)
17. Alemu FM, Yalew AW, Fantahun M, Ashu EE. Antiretroviral Therapy and Pregnancy Outcomes in Developing Countries: A Systematic Review. Int J MCH AIDS [Internet]. 2015 [cited 2019 Apr 12];3(1):31–43.
18. Ezechi OC, Gab-Okafor CV, Oladele DA, Kalejaye OO, Oke BA, Ujah IO. O239 PREGNANCY, OBSTETRIC AND NEONATAL OUTCOME IN HIV POSITIVE NIGERIAN WOMEN. Int J Gynecol Obstet. 2012;
19. Mubyazi GM, Mwwasongo AJ, Makundi EA, Pallangyo K, Malebo HM, Mshana JM, et al. Analyswas of Cost Impact of HIV/AIDS on Health Service Provwasion in Nine Regions, Tanzania: Methodological Challenges and Lessons for Policy [Internet]. Vol. 1, Rwanda Journal of Health Sciences. 2012 [cited 2019 Apr 12]. (15)
20. 2015-16 Demographic and Health Survey and Malaria Indicator Survey Key Findings Tanzania [Internet]. 2016 [cited 2018 Aug 3].
21. Manyahi J, Jullu BS, Abuya MI, Juma J, Kilama B, Sambu V, et al. Tanzania journal of health research [Internet]. Vol. 19, Tanzania Journal of Health Research. National Institute for Medical Research; [cited 2019 Apr 12]. (16)
22. Sovran S. Understanding culture and HIV/AIDS in sub-Saharan Africa. SAHARA J J Soc Asp HIV/AIDS Res Alliance [Internet]. 2013 Mar [cited 2019 Apr 12];10:32–41. (16)
23. Kharsany ABM, Karim QA. HIV Infection and AIDS in Sub-Saharan Africa: Current Status, Challenges and Opportunities. Open AIDS J [Internet]. 2016 [cited 2019 Apr 12];10:34–48.
24. Velayati A-A, Bakayev V, Bahadori M, Tabatabaei S-J, Alaei A, Farahbood A, et al. Religious and cultural traits in HIV/AIDS epidemics in sub-Saharan Africa. Arch Iran Med [Internet]. 2011 Oct [cited 2019 Apr 12];10:486–97. (17)
25. J. H. F, Ntani LL, Florent FY, Mbu Robinson Enow MR. Fetal outcome of HIV positive pregnant women taking highly active antiretroviral therapy at Yaoundé Central Hospital: a cross sectional analytic study. Int J Reprod Contraception, Obstet Gynecol. 2017 Oct 28;6(11):4791.
26. Joseph O, Biodun O, Michael E. Pregnancy outcome among HIV positive women receiving antenatal HAART versus untreated maternal HIV infection. J Coll Physicians Surg Pakwastan. 2011;
27. Nutley T, Gnassou L, Traore M, Bosso AE, Mullen S. Moving data offthe shelf and into action: An intervention to improve data-informed decwasion making in Cô te d’Ivoire. Glob Health Action. 2014;
28. Dadhwal V, Sharma A, Khoiwal K, Deka D, Sarkar P, Vanamail P. Pregnancy Outcomes in HIV-Infected Women: Experience from a Tertiary Cwere Center in India. Int J MCH AIDS. 2017;
29. Rollins NC, Coovadia HM, Bland RM, Coutsoudwas A, Bennwash ML, Patel D, et al. Pregnancy Outcomes in HIV-Infected and Uninfected Women in Rural and Urban South Africa. JAIDS J Acquir Immune Defic Syndr [Internet]. 2012 Mar 1 [cited 2019 Apr 12];44(3):321–8.
30. Lionel J, Aleyamma TK, Varghese L, Buck J, Gopalakrwashnan G, Chaguturu S, et al. HIV and obstetric complications and fetal outcomes in Vellore, India. Trop Doct [Internet]. 2012 Jul [cited 2019 Apr 12];38(3):144–6.
31. Patil S, Bhosale R, Sambwerey P, Gupte N, Suryavanshi N, Sastry J, et al. Impact of maternal human immunodeficiency virus infection on pregnancy and birth outcomes in Pune, India. AIDS Cwere [Internet]. 2011 Dec 16 [cited 2019 Apr 12];23:1562–9. (18)
32. Giakoumelou S, Wheelhouse N, Cuschieri K, Entrican G, Howie SEM, Horne AW. The role of infection in mwascarriage. Hum Reprod Update [Internet]. 2016 [cited 2019 Apr 12];22(1):116.
33. Kim H-Y, Kasonde P, Mwiya M, Thea DM, Kankasa C, Sinkala M, et al. Pregnancy loss and role of infant HIV status on perinatal mortality among HIV-infected women. BMC Pediatr [Internet]. 2012 Dec 31 [cited 2019 Apr 12];12(1):663.
34. Helova A, Akama E, Bukusi EA, Musoke P, Nalwa WZ, Odeny TA, et al. Health facility challenges to the provwasion of Option B+ in western Kenya: a qualitative study. Health Policy Plan [Internet]. 2016 Sep 10 [cited 2019 Apr 12];czw122.
35. World Health Organization (WHO) Global HIV/AIDS response:epidemic update and health sector progress towards universal access:progress report 2014. Geneva, Switzerland: 2011. [Google Scholar]
36. Joint United Nations Programme on HIV/AIDS (UNAIDS) and World Health Organization (WHO). HIV in pregnancy:A Review. Switzerland, Geneva: UNAIDS; 1998. Contract Number:WHO/RHT /98.24. [Google Scholar]
37. World Health Organization (WHO) Antiretro-viral drugs for treating pregnant women and preventing HIV infection in infants:towards universal access. 2010.
Antiretroviral Therapy and Pregnancy Outcomes in Developing Countrie... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948169/
13 of 17 8/26/2019, 4:11 PM
38. Schouten E. Making it Happen:Revising national policies to reflect changes in WHO recommendations for preventing vertical transmission of HIV-Malawi. International AIDS Society 2010. Vienna, Austria: 2010. [Google Scholar]
39. Colebunders RL, Myer L. Antiretrovirals during pregnancy:a note of caution. The Journal of infectious diseases. 2013;208(4):706–7. [PubMed] [Google Scholar
40. Watts DH, Mofenson LM. Antiretrovirals in pregnancy:a note of caution. The Journal of infectious diseases. 2012;206(11):1639–41.[PMC free article] [PubMed] [Google Scholar
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Copyright (c) 2026 Dr Hamza Mohamed mzige MD,Mmed, Assistant. Dr Monica Chiduo MD, Mmed, Dr Elibariki J.Munuo, MD,Mmed

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