Unveiling the Impact of Demographic Factors on Disease Survival: A Multifaceted Examination across Diverse Medical Conditions

Authors

  • Lakshmi Sahitya Cherukuri Independent Researcher
  • Rohan Singh Rajput Headspace Inc
  • Shantanu Neema Syntelli Solutions Inc

DOI:

https://doi.org/10.47941/ijhs.1731
Abstract views: 50
PDF downloads: 36

Keywords:

Survival Analysis, Scikit-Survival, Concordance Index, Disease Survival

Abstract

Purpose: In this research, we studied the intricate interplay between demographic indicators and survival rates across various diseases, aiming to address the gap in comprehensive analyses across multiple conditions.

Methodology: Drawing from a dataset encompassing 9105 critically ill patients from five medical centers in the United States [1], admitted between1989-1991 and 1992-1994, our analysis spans eight disease categories. Leveraging techniques such as Cox-proportional hazard models and machine learning algorithms, we explore the influence of socio-economic status, gender, race, and education on survival outcomes.

Findings: Our findings underscore significant demographic disparities in disease survivability, with ethnicity, gender, and education level showing varying impacts across different medical conditions. Notably, Asians exhibit lower hazards for certain diseases but higher hazards for others, while females demonstrate better survival probabilities compared to males. Moreover, individuals with higher education levels tend to have slightly increased hazards for certain conditions.

Unique Contribution to Theory, Practice, and Policy: The call for comparative analyses across multiple diseases using comprehensive datasets marks a pivotal shift in research strategy. It aims to highlight the interplays and shared risk factors across diseases, contributing significantly to the advancement of theoretical frameworks, the refinement of healthcare practices, and the shaping of informed public health policies. This approach seeks to bridge a critical gap in the literature, offering a foundation for interventions designed to enhance disease management and improve population health outcomes comprehensively.

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References

Vanderbilt University Department of Biostatistics, Professor Frank Harrell 2022, url: https://hbiostat.org/data/

Simard EP, Pfeiffer RM, Engels EA. Mortality due to cancer among people with AIDS: a novel approach using registry-linkage data and population attributable risk methods. AIDS. 2012 Jun 19;26(10):1311-8. doi: 10.1097/QAD.0b013e328353f38e. PMID: 22472857; PMCID: PMC3377813.

Pickwell-Smith BA, Spencer K, Sadeghi MH, et alWhere are the inequalities in colorectal cancer care in a country with universal healthcare? A systematic review and narrative synthesisBMJ Open 2024;14:e080467. doi: 10.1136/bmjopen-2023-080467

Stanbury JF, Baade PD, Yu Y, Yu XQ. Cancer survival in New South Wales, Australia: socioeconomic disparities remain despite overall improvements. BMC Cancer. 2016 Feb 1;16:48. doi: 10.1186/s12885-016-2065-z. PMID: 26832359; PMCID: PMC4736306.

Yu, X.Q., O’Connell, D.L., Gibberd, R.W. et al. Assessing the impact of socio-economic status on cancer survival in New South Wales, Australia 1996–2001. Cancer Causes Control 19, 1383–1390 (2008). https://doi.org/10.1007/s10552-008-9210-1

Catherine Lejeune, Franco Sassi, Libby Ellis, Sara Godward, Vivian Mak, Matthew Day, Bernard Rachet, Socio-economic disparities in access to treatment and their impact on colorectal cancer survival, International Journal of Epidemiology, Volume 39, Issue 3, June 2010, Pages 710–717, https://doi.org/10.1093/ije/dyq048

Mitchell H. Katz, Ling Hsu, Michael Lingo, Greg Woelffer, Sandra K. Schwarcz, Impact of Socioeconomic Status on Survival with AIDS, American Journal of Epidemiology, Volume 148, Issue 3, 1 August 1998, Pages 282–291, https://doi.org/10.1093/oxfordjournals.aje.a009637

Aimilia Exarchakou, Bernard Rachet, Aurélien Belot, Camille Maringe, Michel P Coleman, Impact of national cancer policies on cancer survival trends and socioeconomic inequalities in England, 1996-2013: population based study, the British Medical Journal, (March 2018) https://doi.org/10.1136/bmj.k764

Faisal Maqbool Zahid,Shakeela Ramzan,Shahla Faisal ,Ijaz Hussain, Gender based survival prediction models for heart failure patients: A case study in Pakistan, Feb 2019, https://doi.org/10.1371/journal.pone.0210602

A. Bruandet; F. Richard; S. Bombois; C.A. Maurage; I. Masse; P. Amouyel; F. Pasquier, Cognitive Decline and Survival in Alzheimer’s Disease according to Education Level, Dement Geriatr Cogn Disord (2007) 25 (1): 74–80. https://doi.org/10.1159/000111693

Sameer Sundran, James Lu, Computing the Hazard Ratios Associated With Explanatory Variables Using Machine Learning Models of Survival Data, JCO Clinical Cancer Informatics, Vol 5, Issue 5, https://doi.org/10.1200/CCI.20.00172

Pedregosa F, Varoquaux, Ga"el, Gramfort A, Michel V, Thirion B, Grisel O, et al. Scikit-learn: Machine learning in Python. Journal of machine learning research. 2011;12(Oct):2825–30.

Brentnall AR, Cuzick J. Use of the concordance index for predictors of censored survival data. Statistical Methods in Medical Research. 2018;27(8):2359-2373. doi:10.1177/0962280216680245

Bøvelstad, H. M. et al. Predicting survival from microarray data—A comparative study. Bioinformatics 23, 2080–2087 (2007). https://doi.org/10.1093/bioinformatics/btm305

Van Wieringen, W. N., Kun, D., Hampel, R. & Boulesteix, A. L. Survival prediction using gene expression data: A review and comparison. Comput. Stat. Data Anal. 53, 1590–1603 (2009). https://doi.org/10.1016/j.csda.2008.05.021

Cranford HM, Koru-Sengul T, Lopes G, Pinheiro PS. Lung Cancer Incidence by Detailed Race-Ethnicity. Cancers (Basel). 2023 Apr 5;15(7):2164. doi: 10.3390/cancers15072164. PMID: 37046824; PMCID: PMC10093016.

Wu, XN., Xue, F., Zhang, N. et al. Global burden of liver cirrhosis and other chronic liver diseases caused by specific etiologies from 1990 to 2019. BMC Public Health 24, 363 (2024). https://doi.org/10.1186/s12889-024-17948-6

Lewsey SC, Breathett K. Racial and ethnic disparities in heart failure: current state and future directions. Curr Opin Cardio. 2021 May 1;36(3):320-328. doi: 10.1097/HCO.0000000000000855. PMID: 33741769; PMCID: PMC8130651.

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Published

2024-03-17

How to Cite

Cherukuri , L. S., Rajput , R. S., & Neema, S. (2024). Unveiling the Impact of Demographic Factors on Disease Survival: A Multifaceted Examination across Diverse Medical Conditions. International Journal of Health Sciences, 7(2), 1–14. https://doi.org/10.47941/ijhs.1731

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